Name: liposomal vitamin c powder;liposomal vitamin c liquid
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Liposomal Vitamin C is an enhanced form of the vitamin designed for better nutrient absorption and utilization in the body. Liposomes are small spherical cells with an outer layer composed of fatty acids called phospholipids derived from sunflower or soybeans. Liposomes also have an inner compartment composed of water and water-soluble active ingredients. Water-soluble ingredients such as vitamin C are protected within internal compartments through the liposome structure.

Product Name

liposomal vitamin c

Active Ingredients

vitamin c

Specification

5%-30%liquid，50%-70%powder

Appearance

Yellow viscous liquid or light yellow powder

Inclusion compound excipients

Phospholipids

Desciption

Product information
What is liposomal vitamin c
Liposomal Vitamin C is an enhanced form of the vitamin designed for better nutrient absorption and utilization in the body. Liposomes are small spherical cells with an outer layer composed of fatty acids called phospholipids derived from sunflower or soybeans. Liposomes also have an inner compartment composed of water and water-soluble active ingredients. Water-soluble ingredients such as vitamin C are protected within internal compartments through the liposome structure.

The main advantage of liposomal vitamin C is improved absorption. There is a threshold for the ability of our intestinal cells to take in higher doses of vitamin C. This is why taking higher doses of vitamin C can lead to excessive gas and/or diarrhea. The bioavailability of liposomal vitamin C is significantly higher than that of regular vitamin C, almost twice as much. Oral liposomal vitamin C is often recommended as an alternative to intravenous (IV) vitamin C.
Joyous liposomal vitamin c specification

Terms	Standard	Terms	Standard
Product Name	liposomal vitamin c	Appearance	Yellow viscous liquid or light yellow powder
Assay	5%-30%liquid，50%-70%powder	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

How are liposomal vitamin c made?
When phospholipids are naturally dispersed in water, they form a closed bilayer structure, with one end hydrophilic and the other lipophilic. Joyous liposome dosage forms are made around this characteristic of phospholipids. First, we prepare the water phase and oil phase separately, and then we can use three machines for nano-level packaging processing, which are high-pressure homogenizer, nano micro-jet and ultrasonic micro-jet. In the machine, Joyous products (such as vitamin C) Uniform nanoparticles will gradually be formed during shearing and collision, and then they will be put into another machine for the extrusion process. This part can ensure that we control and screen the nanoparticle size, and in this process After removing the free part (such as vitamin C), the last step is of course the detection step. Observe the cross section of liposome vitamin C through an electron microscope to see if it is consistent with our preset structure, and test the strength and dispersion to confirm whether it is evenly distributed. , finally check the encapsulation rate. If the free part does not exceed 3%, that is to say, when the encapsulation rate reaches at least 97%, this part of the product is qualified. Of course, what we are introducing here is the production process of liquid liposomes.
Powdered liposomes are divided into two situations during the production process. One is crude liposome powder, which is produced in a simulated environment. We have introduced the characteristics of phospholipids before, and Joyous liposomes are based on This characteristic comes from the fact that we mix phospholipids, water and the ingredients we need to package (such as vitamin C), and repeatedly collide and stir them in an environment of constant temperature and pressure, and finally spray dry them into powder and add some medicinal anticoagulants. In this way, crude liposomes are obtained. This kind of liposome is intended to be added to concepts and some low-end supplement products. It can play a certain liposome function, but it is obvious that its function is not It is not as strong as liquid, but the advantage is that the proportion of inclusion compounds is higher (the content can be high enough).
The second situation is based on liquid liposomes, which is also subdivided into two modes. One is to freeze-dry the liposomes into powder in a low-temperature environment that does not destroy the product activity. The disadvantage is that when the liquid becomes When powdered, it will irreversibly change from nanoparticle size to fine powder of 200 mesh to 120 mesh, which means that the penetration and absorption performance is lost. The advantage is that this is a complete liposome, which is more durable than crude liposome powder. Strong. Another situation is what Joyous calls the perfect liposome powder. It undergoes some special processing. After it becomes a powder, if you wash it in water, it can be restored to a nano-scale liposome vitamin liquid with lipid properties. The plasmid itself has almost all functions, but Joyous’ technology has not yet achieved a breakthrough in this type of product, and only some large listed companies have launched it as new drug products.
What are the benefits of liposomes？
As a new type of drug carrier, liposomes have the characteristics of protecting the encapsulated active ingredients from being degraded by the physiological environment, extending the half-life of the drug, controlling the release of drug molecules, and having good biocompatibility and safety. They can also pass through passive and/or active targets. It selectively delivers its encapsulated active ingredients to the diseased site, thereby reducing systemic side effects, increasing the maximum tolerated dose and improving therapeutic effects.
After consulting the relevant drug database and excluding generic drugs, lipoplexes and regionally approved products, a total of 14 liposome products have been approved for marketing worldwide.
Overview of liposome products
The first liposome product on the market was Doxil, a liposome injection of doxorubicin hydrochloride approved by the FDA in 1995. Among the liposome products on the market, 43% were approved before 2000 and 57% were approved before 2010. These liposome products are mainly focused on oncology treatment, but also cover other areas such as infection, anesthesia, vaccines, lung diseases and photodynamic therapy. The dosage forms of these liposome products are mainly sterile suspensions and lyophilized powders. Routes of administration include intravenous infusion, intramuscular and intrathecal injection, epidural administration, local infiltration, and oral inhalation. After the advent of COVID-19, vaccines based on liposome technology also shined.
Some other liposome products approved for marketing, such as malaria vaccine Mosquirix, hepatitis A vaccine Epaxal, influenza vaccine Inflexal, veterinary drug long-acting bupivacaine local anesthetic Nocita, etc. also have good sales.

According to the particle size of liposomes and the number of lipid bilayer membranes, liposomes can be divided into unilamellar liposomes (ULV); oligolamellar lipids (OLV, 100-1000nm); multilamellar liposomes Liposomes (Multilamellarvesicles, MLV, >500nm); Multivesicular liposomes (MVL, >1000nm).
There are four liposome products with particle sizes in the micron range, namely mivamut liposome Mepact, cytarabine liposome suspension DepoCyt, morphine sulfate sustained-release liposome injection DepoDur and bupivacaine Liposome Injectable Suspension Exparel. Mepact is a sterile freeze-dried cake that is reconstituted with 0.9% normal saline to form multilamellar liposomes with a particle size of 2.0~3.5μm. Particles of this size are conducive to recognition and phagocytosis by monocytes/macrophages, and Cancer therapy that triggers macrophage and immunomodulatory effects. DepoCyt, DepoDur and Exparel are produced using the same DepoFoam technology. Due to its many cavities in its structure, MVL can load a large amount of drug solution and achieve sustained release due to the slow erosion/degradation of liposomes and the slow diffusion of drug molecules. Electron microscopy images of Doxil, Vyxeos, DepoCyt and Mepact:

Current commercial products are designed to prolong circulation time, increase half-life, and passively target diseased sites, so most of them are SUVs. For example, the particle size of amikacin liposome inhalation suspension ARIKAYE is larger (200-300nm) and is considered LUV. Daunorubicin cytarabine liposome for injection Vyxeos is a bilayer liposome. This structure is formed during the first loading of cytarabine. The mechanism of internal thin layer formation is Interpreted as a thermodynamic response, the lipid bilayer decreases the surface area to volume ratio due to the penetration of the aqueous medium by external osmotic pressure.
Doxorubicin liposome Myocet and mivamut liposome Mepact are MLVs. A large number of lipid layers provide enough space for encapsulating lipophilic drugs.

Starting from the approval of the first liposome product Doxil in 1995, liposome technology has been developed for more than 20 years. By summarizing the successes and pain points based on numerous publications and commercial products, liposomes can be carefully designed and perform the desired function according to human needs. On the one hand, there are some major obstacles in the development and commercial production process, such as individual differences in the EPR effect, the effect of PEGylated liposomes, the phenomenon of accelerated blood clearance (ABC), process scale-up, different production batches and Site-to-site reproducibility/consistency, and excipient control. On the other hand, a large number of smart liposome systems are being developed in laboratories or undergoing clinical trials, such as active-targeting liposomes (anti-EGFR immunoliposomes, Phase II; MBP-426, Phase II) and sensitive liposomes. Plastids (ThermoDox). The microenvironment of the target lesion can be used to trigger liposomes to release drugs. External or internal stimuli (such as temperature, pH, light, electromagnetic fields, enzymes and hypoxia) are often studied as the "switch" (On-Off) of drug release. ). Although good results have been achieved in preclinical studies, successful clinical translation still faces challenges due to major issues such as vector leakage before reaching the target, individual patient differences, and the multimodal treatments involved. ThermoDox, the fastest-developing thermosensitive liposome, failed in the second phase of a Phase III clinical trial in combination with radiofrequency ablation for hepatocellular carcinoma. However, these failures only mean the failure of liposome products under certain clinical designs. Intelligent technology will provide many more opportunities for liposomes to further improve the efficacy and reduce side effects.
China's State Food and Drug Administration has approved five types of liposome products: paclitaxel liposomes, doxorubicin hydrochloride liposomes, amphotericin liposomes, mitoxantrone hydrochloride liposomes, and irinotecan hydrochloride liposomes Among them, paclitaxel liposomes and mitoxantrone liposomes are unique products in China.

There is little accurate market research data on liposomes. We made some comparisons based on search popularity and searched for literature related to liposomes from 1970 to 2020 on Scopus using liposomes as the keyword. Statistics of these results can be concluded: (1) Liposomes were used as drug carriers in fields such as food and cosmetics earlier than in nanomedicine (1970 vs. 1990); (2) Liposomes were used as drug carriers in liposomes Use in quality-related publications has increased over time, from 50% in 2000 to 70% in 2010 and to 74% in 2020;
(3) Although the development of nanomedicine lags behind the application of liposomes, the number of papers on nanomedicine has increased exponentially over time;
(4) The extremely low proportion of nanodrug liposomes in total nanodrugs (7%) may be due to incorrect data, because there were 3024 publications on liposomal drugs in 2020.
According to the FDA, as of February 18, 2016, more than 500 liposome applications had been received. Of these applications, 3% were NDAs, 1% were ANDAs, and 96% were INDs, except for approximately 100 submissions in which liposomes were used in combination with another therapeutic. Judging from the data collected in laboratories and the pharmaceutical industry, in the near future, there will be a large number of liposome products transformed from the laboratory to pilot production and finally launched on the market.

Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides liposomal vitamin c OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
For more details please click here

Where to buy liposomal vitamin c?
We offer the best liposomal vitamin c at the most competitive price.liposomal vitamin c bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide liposomal vitamin c in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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We provide high-quality products and services, as well as customized pellets. We are a professional ingredient supplier and solution provider.

Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; info@joyouspellets.com; +86 17391747738

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